The correspondence is organized chronologically, with undated correspondence being last.

The bulk of Botsford’s correspondence is mainly to Richard Furman, pastor of Charleston Baptist Church, and Rev. John M. Roberts, pastor of High Hills Baptist Church. The topics pertain to affairs in Botsford’s churches and other Baptist churches in the South Carolina low country, giving his opinions on current events, Baptist work, and mentioning the names of many of the Baptist leaders of the time. Botsford conveys his distress after the death of his second wife in the March 10, 1796 letter and news of the death of his son Jeremiah in the November 3, 1799 letter. The May 20, 1814 letter to Furman contains additions/revisions to Botsford’s A Spiritual Journey. In 1818, there are four letters to his son, Edmund Park Botsford who later died in February 1819. The elder Botsford thought himself to be dying when he wrote the August 19 letter and it contains what he thought was his final advice to his son. Botsford conveys the news of his son’s (Edmund) death to Rev. Richard Furman in the March 6, 1819 letter, and gives condolences to Furman regarding the death of Furman’s second wife, Dorothea, in the March 25, 1819 letter.